pentose phasphate pathway cycle botnay
Vía de las pentosas Ciclo de CalvinUNAM
Pathway(s) Ethanol fermentation Synthesis of acetyl-CoA Citric acid cycle Carbon-assimilation reactions Pentose phosphate pathway OH Pyruvate decarboxylase Pyruvate dehydrogenase a-Ketoglutarate dehydrogenase Transketolase O S-CoA OH c—R5 O —C CH20H c=o CHOH Ketose donor O transketolase Aldose acceptor (a) H CH20H c=o CHOH __-Cl-120H c— OH
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Click to view12 52The pentose phosphate pathway occurs in the cytosol consists of two distinct phases the oxidative and non-oxidative. As for the former the primary result is the conversion of glucose-6-phosphate (G6P) into ribulose-5
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The pentose phosphate pathway (PPP) has recently been shown to have a crucial role in cancer cell growth by pro-viding both nucleotide precursors needed for proliferation and NADPH used for both intracellular ROS detoxi fication and catabolic metabolism1–5. The inhibition of PPP key enzymes including glucose-6-phosphate dehydrogenase
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Pentose Phosphate Pathway (Warburg-Dicken s Pathway) It involves the oxidation of Glucose-6-Phosphate to 6-Phosphogluconic acid which in turn is converted into pentose phosphates. In this pathway glucose-6-phosphate is directly oxidised without entering glycolysis hence it is also known as Direct Oxidation Pathway or Hexose Monophosphate Shunt.
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That is the cell needs ribose 5-phosphate but has a relatively high concentration of NADPH and a low concentration of NADP. -The oxidative pentose phosphate pathway reaction catalyzed by glucose 6-phosphate dehydrogenase is slowed. -Conversion of glycolytic intermediates to ribose 5-phosphate requires transketolase and transaldolase.
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IntroductionPentose Phosphate Pathwayan overview ScienceDirect
The pentose phosphate shunt pathway (Fig. 3.6) has two major roles provision of NADPH that is utilized in biosynthetic reactions and oxidative defense and generation of 5-carbon intermediates that are precursors for nucleic acids (Dringen et al. 2007).Both of these functions are particularly important in developing brain when lipid biosynthesis and cell division are most active.
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The pentose phosphate pathway (PPP) is an alternative way of glucose use. It consists of an aerobic and an anaerobic part. For that reason the PPP can act as a pathway or a cycle both at the same time. Its aerobic part leads to ribulose-5-phosphate carbon dioxide (CO 2) and reduced nicotinamide adenine dinucleotide phosphate (NADPH). One
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electron transport oxidative phosphorylation pentose phosphate pathway photorespiration cyanide resistant respiration. Lipid biosynthesis and its oxidation Unit-III Nitrogen metabolism atmospheric nitrogen fixation nitrogen cycle nitrogen assimilation Growth general aspects of phytohormones and inhibitors-auxins kinetin gibberellins and
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The pentose phosphate pathway oxidizes glucose to make NADPH and other carbohydrates for biosynthesis (see Figure 1 ). The major route for reduction of NADP to NADPH is the reaction of glucose‐6‐phosphate through two successive reactions. In the first carbon 1 of glucose is oxidized from an aldol to an ester form (actually an internal
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